Here’s a breakdown of early experiment results from Diablo 4 Items Season 11 focused on Mythic items (and “sanctification”), noting what’s performing well and what’s flopping — so you can better allocate your resources. Take all data with a grain of salt (PTR/lab conditions, small samples), but the patterns already give strong signals.

What’s Winning

Mythic item re-works and upgrades are paying off

For example, the item Melted Heart of Selig got a buff in Season 11/patch 2.5: “Added an effect that increases your primary resource by 3% per point in your primary stat”. That opens up major resource-tank/buffer builds. (igmeet.com)

Builds with strong Mythic + Paragon + Aspect synergy are dominating the leaderboards in The Tower / The Pit. For instance the “Shadowblight Necromancer” clear reports show high performance thanks to how its Mythic gear scales. (aoeah.com)

Many players on the PTR report decent sanctification outcomes for Mythics: one user did 32 Mythics, and ~40.6% of those got “+ Aspects” results post-sanctification. (Reddit)

Certain classes/builds showing strong performance

The aforementioned Necromancer build is one of them. High clear speed + boss viability.

Some Rogues (dance/knife/multi-hit) appear to be very strong in the meta for Season 11. (aoeah.com)

The Mythic item changes (buffs) are giving previously weak/unused Mythics a second chance. Good value for players who own older Mythics. (igmeet.com)

What’s Failing / Risky

Mythic drop or upgrade rate still feels brutal

Multiple player experiments report very low Mythic drop rates. For example: “I did about 250 Andariel kills… only 3 Mythics out of 3000 items”. (Reddit)

Another user ran 500 Duriel kills and basically had no Mythics they could use. (Reddit)

Sanctification is high-risk

The sanctification system (Season 11’s new risk-reward mechanic) can yield big gains but also ruin an item. Example: One feedback thread says: “Sanctify might replace an affix on your Mythic unique, making it substantially worse.” (Reddit)

The experiment with 32 Mythics showed that ~6.3% had “Replaced Affix” outcome (bad) in sanctification. (Reddit)

Build diversity appears to be shrinking

Some players note fewer viable builds in S11: “Too many builds are basically overshadowed by meta picks.” (Reddit)

If you chase niche Mythics, your payoff may be much lower compared to meta Mythics.

Key Takeaways for Your Play

Invest in Mythics, but stash backup currency/materials (e.g., Resplendent Sparks, crafting runes).

If you own older Mythics that got buffs (like Melted Heart of Selig), they may be better value now than buying a brand-new Mythic.

Before using the sanctification mechanic on a Mythic, make sure you’re comfortable with risk. If you’re using high-value gear, weigh the potential downside.

Focus on builds that are showing strong performance in early data (Necro, Rogue multi-hit, etc.). Niche builds may still work but will require more investment.

Don’t expect Mythics to drop easily — be prepared for long grinds or buy Diablo 4 Items.

If you’re playing in a group or pushing The Tower / The Pit, prioritize Mythics that offer both clear speed and survivability. Pure burst DPS Mythics are great on bosses, but can falter in mapping/rush content.