Omniphobia, Fear Manifest is one of the two major Delirium endgame bosses in Path of Exile 2, standing as a formidable challenge for players farming Delirium content or tackling the Simulacrum.

Alongside Kosis, The Revelation, and Omniphobia represent a pinnacle threat in the nightmare-fueled dreamscapes of the Delirium realm.

This guide will walk you through how to summon the boss, what to expect in the encounter, how to survive, and what unique rewards you can earn.

How to Encounter Omniphobia

There are two main methods to find Omniphobia:

1. Simulacrum (Guaranteed Encounter)

·Combine 300 Simulacrum Splinters to form a Simulacrum Map.

·Omniphobia is guaranteed to appear during the 15-wave Simulacrum event.

·He may appear in waves 15 or earlier, depending on RNG and mechanics.

2. Delirium Maps (Chance Encounter)

·Delirium-affected maps have a random chance to spawn Omniphobia.

·More likely in high-tier, fully Delirious maps.

·Use Delirium Orbs on maps for a better chance at seeing him.

Omniphobia's Unique Drop Table

Omniphobia shares loot with the general Simulacrum Unique pool, so while he doesn't have exclusive loot, he can drop Path of Exile 2 Currency or highly desirable items.

Possible Unique Drops:

·Assailum (Helmet)- Grants Perfect Agony and skills that benefit crit and poison.

·Perfidy (Body Armor)- Adds an extra War Banner/Defiance Banner; popular in melee builds.

·Melting Maelstrom (Mana Flask)- Chaos-damage flask utility.

·Collapsing Horizon (Quarterstaff)- Converts Projectile Attacks into Nova-style effects.

·Strugglescream (Amulet)- Allows 2 Instilled Modifiers; excellent for boosting DPS.

·Megalomaniac (Cluster Jewel)- Randomly grants 3 notable passives from the passive tree.

Strugglescream and Megalomaniac are the most sought-after due to their build-defining potential.

How to Defeat Omniphobia

Omniphobia uses massive AoE attacks, status effects, and close-quarters aggression to crush players. Here's a breakdown of his attack mechanics:

 Axe Slam (Melee + Leap Slam)

·Two to three consecutive ground slams in a wide area.

·Can also perform a leaping slam if you try to kite him.

·Avoidance: Dodge-roll when you see him raise his axe or jump.

Bleed Slash

·A ranged arc-shaped slash that deals physical damage and causes bleeding.

·Bleed damage over time is lethal- don't underestimate it.

·Avoidance: Equip bleed removal flasks or charms with bleed immunity.

 Chaos Vomit (DoT AoE)

·Winds up briefly, then spews out Chaos projectiles in a cone or radial area.

·Leaves behind pools of chaos damage over time.

·Avoidance: Watch for the 1-second pause (casting animation), then move quickly.

Tip: Chaos resistance and movement speed are crucial in this fight. You can buy Path of Exile 2 Currency to exchange bring flasks with anti-bleed and chaos DoT mitigation.

Tips & Strategy

·Stay Mobile: Most of Omniphobia's damage is avoidable with smart movement and rolls.

·Bring Chaos Resistance: The Vomit ability becomes far more manageable with >60% Chaos Res.

·Manage Bleed: Bleed effects can stack and kill quickly if not handled.

·Avoid Corners: Keep the fight in open terrain to avoid getting cornered during slams or vomit phases.

Recommended Builds

While most builds can take on Omniphobia with preparation, these types tend to perform better:

·Ranged Spellcasters- Avoid melee range and kite from a distance.

·Summoners- Let minions absorb damage while you focus on dodging.

·Chaos/DoT Builds- Counteract Omniphobia's tankiness with strong damage over time.

Conclusion

Omniphobia, Fear Manifest, is a fearsome yet rewarding boss that tests your movement, resistance, and build preparation. While he may not have a personal loot table, the Simulacrum Uniques he helps unlock can dramatically improve your character.

If you're planning to farm Simulacrums or delve deep into Delirium maps, prepping for Omniphobia is essential to survive and thrive.